Assay Detail
Functional
CHEMBL5139879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero cells assessed as viral growth inhibition by cell culture based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.76 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | — | 1 | 5.09 |
| CHEMBL1397270 | — | — | 1 | 4.70 |
| CHEMBL549695 | — | — | 1 | 4.49 |
| CHEMBL187460 | CRYPTOTANSHINONE | — | 1 | - |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227075 | DIHYDROTANSHINONE I | EC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL1397270 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL549695 | — | EC50 | = | 32640.0 | nM | 4.49 |
| CHEMBL187460 | CRYPTOTANSHINONE | EC50 | > | 200000.0 | nM | - |
| CHEMBL187266 | TANSHINONE IIA | EC50 | > | 200000.0 | nM | - |