Assay Detail

CHEMBL5139897

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against SARS-CoV-2 infected in African green monkey Vero cells assessed as viral growth inhibition

ChEMBL ↗

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Target

SARS-CoV-2 (CHEMBL4303835) ↗

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Primary target SARS-CoV-2

CHEMBL4303835

Anchored from Assay target.

Protein identity SARS-CoV-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome coronavirus 2
Cell Type	Vero
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome coronavirus 2

Publication

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.

Tan H, Hu Y, Jadhav P, Tan B, Wang J.
J Med Chem (2022) 65 : 7561 -7580
PubMed 35620927 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.19	7.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL55400	PROFLAVINE	2.0	1	7.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL55400	PROFLAVINE	EC50	=	64.0	nM	7.19