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Assay Detail

CHEMBL5140001

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against SARS-CoV-2 WIV04 infected in African green monkey Vero cells assessed as inhibition of viral proliferation measured at 24 hrs post infection by qRT-PCR analysis
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Severe acute respiratory syndrome coronavirus 2
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV-2 (CHEMBL4303835)
Type ORGANISM
Organism Severe acute respiratory syndrome coronavirus 2

Publication

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.
Wang H, Pei R, Li X, Deng W, Xing S, Zhang Y, Zhang C, He S, Sun H, Xiao S, Xiong J, Zhang Y, Chen X, Wang Y, Guo Y, Zhang B, Shang L.
Eur J Med Chem (2022) 238 : 114458 -114458
PubMed 35635946 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 43 5.97 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4764751 1 6.44
CHEMBL5195478 1 5.97
CHEMBL5200040 1 5.96
CHEMBL5199094 1 5.95
CHEMBL5203574 1 5.87
CHEMBL3885329 1 5.82
CHEMBL5174138 1 5.78
CHEMBL5179730 1 -
CHEMBL5203407 1 -
CHEMBL5197105 1 -
CHEMBL5189683 1 -
CHEMBL5192273 1 -
CHEMBL5182755 1 -
CHEMBL5173399 1 -
CHEMBL5173857 1 -
CHEMBL5180964 1 -
CHEMBL5207566 1 -
CHEMBL5205787 1 -
CHEMBL5206326 1 -
CHEMBL5185152 1 -
CHEMBL5199219 1 -
CHEMBL5175884 1 -
CHEMBL5179310 1 -
CHEMBL5191663 1 -
CHEMBL5191197 1 -
CHEMBL5182229 1 -
CHEMBL5192541 1 -
CHEMBL5169416 1 -
CHEMBL5198279 1 -
CHEMBL5179883 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4764751 EC50 = 360.0 nM 6.44
CHEMBL5195478 EC50 = 1060.0 nM 5.97
CHEMBL5200040 EC50 = 1110.0 nM 5.96
CHEMBL5199094 EC50 = 1130.0 nM 5.95
CHEMBL5203574 EC50 = 1360.0 nM 5.87
CHEMBL3885329 EC50 = 1510.0 nM 5.82
CHEMBL5174138 EC50 = 1670.0 nM 5.78
CHEMBL5173857 EC50 > 3000.0 nM -
CHEMBL5201697 EC50 > 3000.0 nM -
CHEMBL5180964 EC50 > 3000.0 nM -
CHEMBL5207566 EC50 > 3000.0 nM -
CHEMBL5205787 EC50 > 3000.0 nM -
CHEMBL5203407 EC50 > 3000.0 nM -
CHEMBL3884779 EC50 > 3000.0 nM -
CHEMBL5182830 EC50 > 3000.0 nM -
CHEMBL5186446 EC50 > 3000.0 nM -
CHEMBL5207769 EC50 > 3000.0 nM -
CHEMBL5197113 EC50 > 3000.0 nM -
CHEMBL5172144 EC50 > 3000.0 nM -
CHEMBL5190907 EC50 > 3000.0 nM -
CHEMBL5183017 EC50 > 3000.0 nM -
CHEMBL5176330 EC50 > 3000.0 nM -
CHEMBL5189974 EC50 > 3000.0 nM -
CHEMBL5207843 EC50 > 3000.0 nM -
CHEMBL5189874 EC50 > 3000.0 nM -
CHEMBL5175884 EC50 > 3000.0 nM -
CHEMBL5179883 EC50 > 3000.0 nM -
CHEMBL5198279 EC50 > 3000.0 nM -
CHEMBL5169416 EC50 > 3000.0 nM -
CHEMBL5192541 EC50 > 3000.0 nM -
CHEMBL5182229 EC50 > 3000.0 nM -
CHEMBL5191197 EC50 > 3000.0 nM -
CHEMBL5191663 EC50 > 3000.0 nM -
CHEMBL5179310 EC50 > 3000.0 nM -
CHEMBL5173399 EC50 > 3000.0 nM -
CHEMBL5199219 EC50 > 3000.0 nM -
CHEMBL5185152 EC50 > 3000.0 nM -
CHEMBL5206326 EC50 > 3000.0 nM -
CHEMBL5179730 EC50 > 3000.0 nM -
CHEMBL5197105 EC50 > 3000.0 nM -
CHEMBL5189683 EC50 > 3000.0 nM -
CHEMBL5192273 EC50 > 3000.0 nM -
CHEMBL5182755 EC50 > 3000.0 nM -