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Assay Detail

CHEMBL5140299

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SW480 cells assessed as cell growth inhibition incubated for 48 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW480
Confidence 1 — Organism
Curated By Autocuration

Target

SW480 (CHEMBL612544)
Type CELL-LINE
Organism Homo sapiens

Publication

Total Syntheses and Cytotoxicity Evaluation of Coryaurone A and Representative Analogues.
Tian T, Li M, Feng W, Ding Y, Li Z, Shi Z, Shen T.
J Nat Prod (2022) 85 : 1634 -1640
PubMed 35671109 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.81 5.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5171350 1 5.11
CHEMBL2437369 LICOAGROAURONE 1 5.09
CHEMBL5197805 1 5.04
CHEMBL5184584 1 4.96
CHEMBL3577245 1 4.89
CHEMBL5187150 1 4.70
CHEMBL5197363 1 4.64
CHEMBL5178663 1 4.46
CHEMBL5178998 1 4.41
CHEMBL5191387 1 -
CHEMBL5186587 1 -
CHEMBL5195476 1 -
CHEMBL5183494 1 -
CHEMBL5203426 1 -
CHEMBL5170766 1 -
CHEMBL5200974 1 -
CHEMBL5202175 1 -
CHEMBL5179528 1 -
CHEMBL5179048 1 -
CHEMBL5176923 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5171350 IC50 = 7700.0 nM 5.11
CHEMBL2437369 LICOAGROAURONE IC50 = 8200.0 nM 5.09
CHEMBL5197805 IC50 = 9200.0 nM 5.04
CHEMBL5184584 IC50 = 11000.0 nM 4.96
CHEMBL3577245 IC50 = 13000.0 nM 4.89
CHEMBL5187150 IC50 = 20000.0 nM 4.70
CHEMBL5197363 IC50 = 23000.0 nM 4.64
CHEMBL5178663 IC50 = 35000.0 nM 4.46
CHEMBL5178998 IC50 = 39000.0 nM 4.41
CHEMBL5191387 IC50 > 40000.0 nM -
CHEMBL5186587 IC50 > 40000.0 nM -
CHEMBL5195476 IC50 > 40000.0 nM -
CHEMBL5183494 IC50 > 40000.0 nM -
CHEMBL5203426 IC50 > 40000.0 nM -
CHEMBL5170766 IC50 > 40000.0 nM -
CHEMBL5200974 IC50 > 40000.0 nM -
CHEMBL5202175 IC50 > 40000.0 nM -
CHEMBL5179528 IC50 > 40000.0 nM -
CHEMBL5179048 IC50 > 40000.0 nM -
CHEMBL5176923 IC50 > 40000.0 nM -