Assay Detail
Binding
CHEMBL5140369
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Inhibition of recombinant wild-type p66/p51 HIV-1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.93 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.96 |
| CHEMBL5174000 | — | — | 1 | 7.13 |
| CHEMBL5205629 | — | — | 1 | 7.10 |
| CHEMBL5187988 | — | — | 1 | 7.10 |
| CHEMBL5197703 | — | — | 1 | 7.00 |
| CHEMBL5180920 | — | — | 1 | 6.80 |
| CHEMBL5190637 | — | — | 1 | 6.70 |
| CHEMBL5188407 | — | — | 1 | 6.65 |
| CHEMBL5174481 | — | — | 1 | 6.63 |
| CHEMBL5173017 | — | — | 1 | 6.57 |
| CHEMBL5186337 | — | — | 1 | 6.33 |
| CHEMBL5176289 | — | — | 1 | 6.32 |
| CHEMBL5203279 | — | — | 1 | 6.24 |
| CHEMBL5192943 | — | — | 1 | 6.18 |
| CHEMBL5183294 | — | — | 1 | 6.17 |
| CHEMBL5201823 | — | — | 1 | 6.15 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.15 |
| CHEMBL5190744 | — | — | 1 | 6.14 |
| CHEMBL5190141 | — | — | 1 | 6.08 |
| CHEMBL5195817 | — | — | 1 | 5.98 |
| CHEMBL5201738 | — | — | 1 | 5.89 |
| CHEMBL5186285 | — | — | 1 | 5.87 |
| CHEMBL374286 | — | — | 1 | 5.82 |
| CHEMBL5180025 | — | — | 1 | 5.75 |
| CHEMBL5191672 | — | — | 1 | 5.67 |
| CHEMBL5170094 | — | — | 1 | 5.59 |
| CHEMBL5202355 | — | — | 1 | 5.57 |
| CHEMBL5193413 | — | — | 1 | 5.47 |
| CHEMBL5183658 | — | — | 1 | 5.45 |
| CHEMBL5204500 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5174000 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5187988 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5205629 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5197703 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5180920 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5190637 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL5188407 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL5174481 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL5173017 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL5186337 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL5176289 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL5203279 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5192943 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL5183294 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5201823 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL5190744 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL5190141 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL5195817 | — | IC50 | = | 1056.0 | nM | 5.98 |
| CHEMBL5201738 | — | IC50 | = | 1288.0 | nM | 5.89 |
| CHEMBL5186285 | — | IC50 | = | 1354.0 | nM | 5.87 |
| CHEMBL374286 | — | IC50 | = | 1513.0 | nM | 5.82 |
| CHEMBL5180025 | — | IC50 | = | 1779.0 | nM | 5.75 |
| CHEMBL5191672 | — | IC50 | = | 2149.0 | nM | 5.67 |
| CHEMBL5170094 | — | IC50 | = | 2585.0 | nM | 5.59 |
| CHEMBL5202355 | — | IC50 | = | 2705.0 | nM | 5.57 |
| CHEMBL5193413 | — | IC50 | = | 3366.0 | nM | 5.47 |
| CHEMBL5183658 | — | IC50 | = | 3519.0 | nM | 5.45 |
| CHEMBL5204500 | — | IC50 | = | 5992.0 | nM | 5.22 |
| CHEMBL5170052 | — | IC50 | = | 6587.0 | nM | 5.18 |
| CHEMBL5181568 | — | IC50 | = | 9397.0 | nM | 5.03 |
| CHEMBL5208866 | — | IC50 | = | 13266.0 | nM | 4.88 |
| CHEMBL5175287 | — | IC50 | = | 13078.0 | nM | 4.88 |
| CHEMBL5174260 | — | IC50 | = | 14266.0 | nM | 4.85 |
| CHEMBL5199869 | — | IC50 | = | 20669.0 | nM | 4.68 |
| CHEMBL5169873 | — | IC50 | = | 55122.0 | nM | 4.26 |
| CHEMBL5171797 | — | IC50 | = | 83820.0 | nM | 4.08 |
| CHEMBL5171760 | — | IC50 | = | 317725.0 | nM | - |
| CHEMBL5188648 | — | IC50 | = | 203360.0 | nM | - |