Assay Detail
Functional
CHEMBL5140686
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Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as reduction in HBsAg level in cellular supernatant by luminescence based microplate reader analysis
38
Total Activities
37
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of dihydroquinolizinone derivatives with cyclic ether moieties as new anti-HBV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.37 | 9.70 |
| EC50 | 12 | 7.82 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180441 | — | — | 1 | 9.70 |
| CHEMBL5206918 | — | — | 1 | 9.70 |
| CHEMBL5169583 | — | — | 1 | 9.10 |
| CHEMBL4284226 | — | — | 2 | 9.00 |
| CHEMBL5203441 | — | — | 1 | 8.96 |
| CHEMBL5186164 | — | — | 1 | 8.96 |
| CHEMBL5198141 | — | — | 1 | 8.92 |
| CHEMBL5189086 | — | — | 1 | 8.92 |
| CHEMBL5197434 | — | — | 1 | 8.92 |
| CHEMBL5173707 | — | — | 1 | 8.85 |
| CHEMBL5200210 | — | — | 1 | 8.82 |
| CHEMBL5199892 | — | — | 1 | 8.82 |
| CHEMBL5193379 | — | — | 1 | 8.80 |
| CHEMBL5183390 | — | — | 1 | 8.80 |
| CHEMBL5208025 | — | — | 1 | 8.80 |
| CHEMBL5187374 | — | — | 1 | 8.77 |
| CHEMBL5185557 | — | — | 1 | 8.72 |
| CHEMBL5173167 | — | — | 1 | 8.47 |
| CHEMBL5185045 | — | — | 1 | 8.46 |
| CHEMBL5200442 | — | — | 1 | 8.46 |
| CHEMBL5177922 | — | — | 1 | 8.43 |
| CHEMBL5200859 | — | — | 1 | 8.34 |
| CHEMBL5185572 | — | — | 1 | 8.29 |
| CHEMBL5198906 | — | — | 1 | 8.29 |
| CHEMBL5192186 | — | — | 1 | 8.20 |
| CHEMBL5190543 | — | — | 1 | 8.12 |
| CHEMBL5179481 | — | — | 1 | 8.11 |
| CHEMBL5205341 | — | — | 1 | 7.74 |
| CHEMBL5180911 | — | — | 1 | 7.74 |
| CHEMBL5206176 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206918 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5180441 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5169583 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4284226 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5186164 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5203441 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5198141 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5189086 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5197434 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5173707 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5200210 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5199892 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5208025 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5183390 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5193379 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5187374 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5185557 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5173167 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5200442 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5185045 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5177922 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5200859 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4284226 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5185572 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5198906 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5192186 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5190543 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5179481 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5205341 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL5180911 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL5206176 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL5195944 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL5172176 | — | EC50 | = | 239.1 | nM | 6.62 |
| CHEMBL5208401 | — | IC50 | = | 403.1 | nM | 6.39 |
| CHEMBL5195720 | — | IC50 | = | 509.2 | nM | 6.29 |
| CHEMBL5196692 | — | EC50 | = | 881.9 | nM | 6.05 |
| CHEMBL4294968 | — | EC50 | = | 928.4 | nM | 6.03 |
| CHEMBL5203664 | — | EC50 | = | 3081.0 | nM | 5.51 |