Assay Detail

CHEMBL5140968

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Functional

Antiproliferative activity against human 22Rv1 cells expressing Androgen receptor H874Y mutant

ChEMBL ↗

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Target

CWR22R (CHEMBL612657) ↗

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Primary target CWR22R

CHEMBL612657

Anchored from Assay target.

Protein identity CWR22R

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CWR22R
Confidence	1 — Organism
Curated By	Autocuration

Target

CWR22R (CHEMBL612657) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Therapeutic Strategies to Target the Androgen Receptor.

Xiang W, Wang S.
J Med Chem (2022) 65 : 8772 -8797
PubMed 35786895 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.66	6.66

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2441094	—	—	1	6.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2441094	—	IC50	=	220.0	nM	6.66