Assay Detail
Binding
CHEMBL5141080
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Agonist activity at Nurr1 in rat N27-A cells measured by NBRE-based luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | N27-A |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL4523278) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.41 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495 | ALPROSTADIL | 4.0 | 1 | 5.52 |
| CHEMBL1084644 | PROSTAGLANDIN A1 | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495 | ALPROSTADIL | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1084644 | PROSTAGLANDIN A1 | EC50 | = | 5000.0 | nM | 5.30 |