Assay Detail
Binding
CHEMBL5141994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
<i>N</i>-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.31 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180161 | — | — | 1 | 9.70 |
| CHEMBL5193821 | — | — | 1 | 9.52 |
| CHEMBL5171223 | — | — | 1 | 9.52 |
| CHEMBL5187184 | — | — | 1 | 9.30 |
| CHEMBL5186161 | — | — | 1 | 9.25 |
| CHEMBL5198030 | — | — | 1 | 9.22 |
| CHEMBL5206111 | — | — | 1 | 9.10 |
| CHEMBL5209113 | — | — | 1 | 8.96 |
| CHEMBL5193591 | — | — | 1 | 8.96 |
| CHEMBL5077508 | — | — | 1 | 8.92 |
| CHEMBL5197263 | — | — | 1 | 8.72 |
| CHEMBL5176109 | — | — | 1 | 8.64 |
| CHEMBL5205042 | — | — | 1 | 8.62 |
| CHEMBL5207423 | — | — | 1 | 8.62 |
| CHEMBL5197809 | — | — | 1 | 8.55 |
| CHEMBL5193091 | — | — | 1 | 8.33 |
| CHEMBL5178023 | — | — | 1 | 8.28 |
| CHEMBL5170313 | — | — | 1 | 8.24 |
| CHEMBL5181951 | — | — | 1 | 8.21 |
| CHEMBL5201357 | — | — | 1 | 8.00 |
| CHEMBL5197655 | — | — | 1 | 7.96 |
| CHEMBL5184263 | — | — | 1 | 7.85 |
| CHEMBL5209156 | — | — | 1 | 7.80 |
| CHEMBL5193667 | — | — | 1 | 7.66 |
| CHEMBL5175690 | — | — | 1 | 7.64 |
| CHEMBL5189556 | — | — | 1 | 7.50 |
| CHEMBL5201472 | — | — | 1 | 6.52 |
| CHEMBL5199042 | — | — | 1 | 5.85 |
| CHEMBL5191554 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180161 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5193821 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5171223 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5187184 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5186161 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL5198030 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5206111 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5209113 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5193591 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5077508 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5197263 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5176109 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5205042 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5207423 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5197809 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5193091 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5178023 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5170313 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5181951 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5201357 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5197655 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5184263 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5209156 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5193667 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5175690 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5189556 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5201472 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL5199042 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5191554 | — | IC50 | = | 3600.0 | nM | 5.44 |