Assay Detail
Functional
CHEMBL5142052
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Vascular Disrupting Agent Inhibiting Tubulin Polymerization and HDACs with Potent Antitumor Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.05 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866085 | — | — | 1 | 7.58 |
| CHEMBL5191492 | — | — | 1 | 7.52 |
| CHEMBL5202479 | — | — | 1 | 7.00 |
| CHEMBL5178565 | — | — | 1 | 6.98 |
| CHEMBL5186345 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866085 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5191492 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5202479 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL5178565 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5186345 | — | IC50 | = | 642.0 | nM | 6.19 |