Assay Detail
Binding
CHEMBL5142246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 1 hr by absorbance based microplate reader analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.18 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 6.43 |
| CHEMBL274452 | — | — | 1 | 5.45 |
| CHEMBL5172850 | — | — | 1 | 5.30 |
| CHEMBL5187479 | — | — | 1 | 5.12 |
| CHEMBL5207121 | — | — | 1 | 5.08 |
| CHEMBL2030639 | — | — | 1 | 5.07 |
| CHEMBL5188549 | — | — | 1 | 4.86 |
| CHEMBL5195156 | — | — | 1 | 4.78 |
| CHEMBL5207671 | — | — | 1 | 4.49 |
| CHEMBL5180636 | — | — | 1 | - |
| CHEMBL5185419 | — | — | 1 | - |
| CHEMBL5184595 | — | — | 1 | - |
| CHEMBL5194494 | — | — | 1 | - |
| CHEMBL38596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL274452 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL5172850 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL5187479 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL5207121 | — | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL2030639 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL5188549 | — | IC50 | = | 13880.0 | nM | 4.86 |
| CHEMBL5195156 | — | IC50 | = | 16490.0 | nM | 4.78 |
| CHEMBL5207671 | — | IC50 | = | 32710.0 | nM | 4.49 |
| CHEMBL5180636 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5185419 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5184595 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5194494 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL38596 | — | IC50 | > | 50000.0 | nM | - |