Assay Detail
Binding
CHEMBL5142292
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Displacement of 125I-labeled angiotensin I from from human plasma renin by gamma counter based competitive radioimmunoassay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.13 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4110551 | SITOKIREN | 3.0 | 1 | 9.35 |
| CHEMBL5174310 | — | — | 1 | 9.15 |
| CHEMBL4114302 | — | — | 1 | 8.85 |
| CHEMBL5187830 | — | — | 1 | 8.74 |
| CHEMBL5200104 | — | — | 1 | 8.59 |
| CHEMBL5188936 | — | — | 1 | 8.19 |
| CHEMBL5176170 | — | — | 1 | 7.72 |
| CHEMBL5190224 | — | — | 1 | 7.48 |
| CHEMBL3699637 | — | — | 1 | 7.08 |
| CHEMBL5184827 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4110551 | SITOKIREN | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5174310 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4114302 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5187830 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5200104 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5188936 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5176170 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5190224 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3699637 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5184827 | — | IC50 | = | 661.0 | nM | 6.18 |