Assay Detail
Functional
CHEMBL5142328
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Antiviral activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chick embryo fibroblast assessed as reduction in virus-induced cytopathic effect preincubated with virus for 30 mins followed by cell addition and measured after 48 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors <i>via</i> Targeting 150-Cavity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.70 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196665 | — | — | 1 | 6.24 |
| CHEMBL5191374 | — | — | 1 | 6.15 |
| CHEMBL5197351 | — | — | 1 | 6.13 |
| CHEMBL5200599 | — | — | 1 | 5.93 |
| CHEMBL5192935 | — | — | 1 | 5.90 |
| CHEMBL5196288 | — | — | 1 | 5.84 |
| CHEMBL5201314 | — | — | 1 | 5.68 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.21 |
| CHEMBL5174598 | — | — | 1 | 5.08 |
| CHEMBL5192262 | — | — | 1 | 4.79 |
| CHEMBL5196029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196665 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5191374 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5197351 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5200599 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5192935 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5196288 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5201314 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5174598 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5192262 | — | EC50 | = | 16050.0 | nM | 4.79 |
| CHEMBL5196029 | — | EC50 | > | 50000.0 | nM | - |