Assay Detail
Functional
CHEMBL5142964
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Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days in presence of ferroptosis inhibitor, liproxstatin-1 by methylene blue staining based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.15 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779501 | — | — | 1 | 5.54 |
| CHEMBL4757878 | — | — | 1 | 5.51 |
| CHEMBL5189423 | — | — | 1 | 5.10 |
| CHEMBL1951048 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779501 | — | IC50 | = | 2879.0 | nM | 5.54 |
| CHEMBL4757878 | — | IC50 | = | 3098.0 | nM | 5.51 |
| CHEMBL5189423 | — | IC50 | = | 7894.0 | nM | 5.10 |
| CHEMBL1951048 | — | IC50 | = | 34515.0 | nM | 4.46 |