Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5143765

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative against in mouse Ba/F3 EGFR-Del19/T790M/C797S cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Ba/F3 EGFR-Del19/T790M/C797S
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
Shaikh M, Shinde Y, Pawara R, Noolvi M, Surana S, Ahmad I, Patel H.
J Med Chem (2022) 65 : 1008 -1046
PubMed 34323489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.68 8.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4443483 1 8.45
CHEMBL5174418 1 8.05
CHEMBL5179884 1 8.05
CHEMBL5195749 1 8.00
CHEMBL5195167 1 7.92
CHEMBL5169450 1 7.66
CHEMBL3545311 BRIGATINIB 4.0 1 7.17
CHEMBL3353410 OSIMERTINIB 4.0 1 6.14
CHEMBL5204787 1 -
CHEMBL5177840 1 -
CHEMBL5190518 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4443483 IC50 = 3.54 nM 8.45
CHEMBL5174418 IC50 = 9.0 nM 8.05
CHEMBL5179884 IC50 = 9.0 nM 8.05
CHEMBL5195749 IC50 = 10.0 nM 8.00
CHEMBL5195167 IC50 = 12.0 nM 7.92
CHEMBL5169450 IC50 = 22.0 nM 7.66
CHEMBL3545311 BRIGATINIB IC50 = 67.2 nM 7.17
CHEMBL3353410 OSIMERTINIB IC50 = 729.6 nM 6.14
CHEMBL5204787 IC50 <= 100.0 nM -
CHEMBL5177840 IC50 <= 100.0 nM -
CHEMBL5190518 IC50 <= 100.0 nM -