Assay Detail
Binding
CHEMBL5143767
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Inhibition of p-EGFR Del19/T790M/C797S triple mutant in mouse BaF3 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.66 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537790 | — | — | 1 | 9.22 |
| CHEMBL4591327 | — | — | 1 | 6.10 |
| CHEMBL5204787 | — | — | 1 | - |
| CHEMBL5177840 | — | — | 1 | - |
| CHEMBL5190518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537790 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4591327 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5204787 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL5177840 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL5190518 | — | IC50 | <= | 100.0 | nM | - |