Assay Detail
Binding
CHEMBL5143813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST fused HER2 (679 to 1255 residues) (unknown origin) using poly (Glu-Tyr) E4Y1 peptide as substrate measured after 4 hrs by ADP-Glo reagent method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.16 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989868 | TUCATINIB | 4.0 | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989868 | TUCATINIB | IC50 | = | 6.9 | nM | 8.16 |