Assay Detail
Functional
CHEMBL5144038
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Antiproliferative activity against human Ca-Ski cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ca-Ski |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.94 |
| CHEMBL5172262 | — | — | 1 | 6.75 |
| CHEMBL5190397 | — | — | 1 | 6.13 |
| CHEMBL5184091 | — | — | 1 | 6.11 |
| CHEMBL4476753 | — | — | 1 | 6.06 |
| CHEMBL5191647 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 11.44 | nM | 7.94 |
| CHEMBL5172262 | — | IC50 | = | 179.6 | nM | 6.75 |
| CHEMBL5190397 | — | IC50 | = | 733.1 | nM | 6.13 |
| CHEMBL5184091 | — | IC50 | = | 785.4 | nM | 6.11 |
| CHEMBL4476753 | — | IC50 | = | 879.1 | nM | 6.06 |
| CHEMBL5191647 | — | IC50 | = | 927.4 | nM | 6.03 |