Assay Detail
Functional
CHEMBL5144039
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.42 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 9.07 |
| CHEMBL5172262 | — | — | 1 | 7.07 |
| CHEMBL5184091 | — | — | 1 | 6.18 |
| CHEMBL5190397 | — | — | 1 | 5.99 |
| CHEMBL5191647 | — | — | 1 | 5.97 |
| CHEMBL4476753 | — | — | 1 | 5.79 |
| CHEMBL2169920 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 0.8581 | nM | 9.07 |
| CHEMBL5172262 | — | IC50 | = | 85.4 | nM | 7.07 |
| CHEMBL5184091 | — | IC50 | = | 666.9 | nM | 6.18 |
| CHEMBL5190397 | — | IC50 | = | 1033.0 | nM | 5.99 |
| CHEMBL5191647 | — | IC50 | = | 1078.0 | nM | 5.97 |
| CHEMBL4476753 | — | IC50 | = | 1635.0 | nM | 5.79 |
| CHEMBL2169920 | — | IC50 | = | 13100.0 | nM | 4.88 |