Assay Detail
Binding
CHEMBL5144149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human IDO1 expressed in Escherichia coli assessed as reduction in formation of N-formylkynurenine by measuring apparent inhibition constant using L-tryptophan as substrate preincubated with compound for 5 mins followed substrate addition by ascorbate/methylene blue assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.03 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | Ki | = | 94.0 | nM | 7.03 |