Assay Detail
Binding
CHEMBL5144239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by Western blot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.65 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185218 | — | — | 1 | 6.29 |
| CHEMBL1797137 | — | — | 1 | 5.90 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.59 |
| CHEMBL470172 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185218 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1797137 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL470172 | — | IC50 | = | 15370.0 | nM | 4.81 |