Assay Detail
Binding
CHEMBL5144467
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Binding affinity to calf thymus DNA assessed as intercalation by measuring dissociation constant at 20 uM measured after 5 mins by UV-Vis spectrophotometric titration analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Acridine-O<sup>6</sup>-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 4.77 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205895 | — | — | 1 | 4.87 |
| CHEMBL5203243 | — | — | 1 | 4.84 |
| CHEMBL76954 | — | — | 1 | 4.79 |
| CHEMBL5200059 | — | — | 1 | 4.79 |
| CHEMBL5185198 | — | — | 1 | 4.72 |
| CHEMBL5189291 | — | — | 1 | 4.63 |
| CHEMBL5207519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205895 | — | Kd | = | 13400.0 | nM | 4.87 |
| CHEMBL5203243 | — | Kd | = | 14300.0 | nM | 4.84 |
| CHEMBL76954 | — | Kd | = | 16100.0 | nM | 4.79 |
| CHEMBL5200059 | — | Kd | = | 16200.0 | nM | 4.79 |
| CHEMBL5185198 | — | Kd | = | 19100.0 | nM | 4.72 |
| CHEMBL5189291 | — | Kd | = | 23400.0 | nM | 4.63 |
| CHEMBL5207519 | — | Kd | - | — | - |