Assay Detail
Binding
CHEMBL5144469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of ethidium bromide from calf thymus DNA incubated for 30 mins by fluorescence microplate reader assay
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Acridine-O<sup>6</sup>-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 6 | - | - |
| EC50 | 1 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76954 | — | — | 1 | 5.10 |
| CHEMBL5200059 | — | — | 1 | - |
| CHEMBL5189291 | — | — | 1 | - |
| CHEMBL5203243 | — | — | 1 | - |
| CHEMBL5185198 | — | — | 1 | - |
| CHEMBL5207519 | — | — | 1 | - |
| CHEMBL5205895 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76954 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5200059 | — | Activity | - | — | - | |
| CHEMBL5189291 | — | Activity | - | — | - | |
| CHEMBL5203243 | — | Activity | - | — | - | |
| CHEMBL5185198 | — | Activity | - | — | - | |
| CHEMBL5207519 | — | Activity | - | — | - | |
| CHEMBL5205895 | — | Activity | - | — | - |