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Assay Detail

CHEMBL5144542

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells assessed as inhibition of cell growth
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.
Li C, Tu J, Han G, Liu N, Sheng C.
Eur J Med Chem (2022) 227 : 113961 -113961
PubMed 34742014 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.96 7.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5173896 1 7.62
CHEMBL5202087 1 7.62
CHEMBL5178633 1 7.62
CHEMBL5199805 1 7.62
CHEMBL5179744 1 5.80
CHEMBL5170389 1 5.80
CHEMBL5200854 1 5.80
CHEMBL5208287 1 5.34
CHEMBL5196645 1 5.34
CHEMBL5207012 1 5.34
CHEMBL5193456 1 5.34
CHEMBL5178170 1 5.34
CHEMBL5197820 1 5.34
CHEMBL5191630 1 5.34
CHEMBL5190934 1 5.34
CHEMBL5170479 1 5.34
CHEMBL5180801 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5173896 IC50 = 24.0 nM 7.62
CHEMBL5202087 IC50 = 24.0 nM 7.62
CHEMBL5178633 IC50 = 24.0 nM 7.62
CHEMBL5199805 IC50 = 24.0 nM 7.62
CHEMBL5179744 IC50 = 1600.0 nM 5.80
CHEMBL5170389 IC50 = 1600.0 nM 5.80
CHEMBL5200854 IC50 = 1600.0 nM 5.80
CHEMBL5208287 IC50 = 4600.0 nM 5.34
CHEMBL5196645 IC50 = 4600.0 nM 5.34
CHEMBL5207012 IC50 = 4600.0 nM 5.34
CHEMBL5193456 IC50 = 4600.0 nM 5.34
CHEMBL5178170 IC50 = 4600.0 nM 5.34
CHEMBL5197820 IC50 = 4600.0 nM 5.34
CHEMBL5191630 IC50 = 4600.0 nM 5.34
CHEMBL5190934 IC50 = 4600.0 nM 5.34
CHEMBL5170479 IC50 = 4600.0 nM 5.34
CHEMBL5180801 IC50 = 4600.0 nM 5.34