Assay Detail

CHEMBL5144553

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of fungal HSP90 incubated for 6 hrs in presence of FITC-Geldanamycin by fluorescence polarization analysis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Fungi
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.

Li C, Tu J, Han G, Liu N, Sheng C.
Eur J Med Chem (2022) 227 : 113961 -113961
PubMed 34742014 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.13	6.18

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2103879	GANETESPIB	3.0	1	6.18
CHEMBL5178170	—	—	1	6.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2103879	GANETESPIB	IC50	=	660.0	nM	6.18
CHEMBL5178170	—	IC50	=	830.0	nM	6.08