Assay Detail
Functional
CHEMBL5144779
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Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation measured after 68 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Structure Correction, and Biosynthesis of Actinopyrones, Cytotoxic Polyketides from the Deep-Sea Hydrothermal-Vent-Derived <i>Streptomyces</i> sp. SCSIO ZS0520.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.70 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL5209341 | — | — | 1 | 6.18 |
| CHEMBL5178851 | — | — | 1 | - |
| CHEMBL5183823 | — | — | 1 | - |
| CHEMBL5201271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5209341 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5178851 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5183823 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5201271 | — | IC50 | > | 50000.0 | nM | - |