Assay Detail
Binding
CHEMBL5144871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DPDPE from recombinant human DOR expressed in CHO cell membranes measured after 2 hrs by microbeta scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.06 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178511 | — | — | 1 | 9.28 |
| CHEMBL5186730 | — | — | 1 | 8.78 |
| CHEMBL5175717 | — | — | 1 | 8.30 |
| CHEMBL5200218 | — | — | 1 | 8.29 |
| CHEMBL5170301 | — | — | 1 | 8.29 |
| CHEMBL5208385 | — | — | 1 | 8.25 |
| CHEMBL5185996 | — | — | 1 | 7.71 |
| CHEMBL5200992 | — | — | 1 | 7.69 |
| CHEMBL5200050 | — | — | 1 | 7.63 |
| CHEMBL485583 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178511 | — | Ki | = | 0.522 | nM | 9.28 |
| CHEMBL5186730 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL5175717 | — | Ki | = | 4.98 | nM | 8.30 |
| CHEMBL5200218 | — | Ki | = | 5.18 | nM | 8.29 |
| CHEMBL5170301 | — | Ki | = | 5.14 | nM | 8.29 |
| CHEMBL5208385 | — | Ki | = | 5.68 | nM | 8.25 |
| CHEMBL5185996 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL5200992 | — | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL5200050 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL485583 | — | Ki | = | 408.0 | nM | 6.39 |