Assay Detail
Binding
CHEMBL5144882
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Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence spectrophotometric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.15 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17594 | QUINIZARIN | — | 1 | 7.19 |
| CHEMBL5201468 | — | — | 1 | 6.24 |
| CHEMBL186784 | XANTHONE | — | 1 | 6.21 |
| CHEMBL86771 | — | — | 1 | 5.97 |
| CHEMBL5196838 | — | — | 1 | 5.91 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 5.75 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | — | 1 | 5.72 |
| CHEMBL124440 | ANTHRONE | — | 1 | 5.72 |
| CHEMBL89626 | — | — | 1 | 5.64 |
| CHEMBL289277 | EMODIN | — | 1 | 5.37 |
| CHEMBL294264 | PURPURIN | — | 1 | 5.10 |
| CHEMBL53418 | DANTHRON | 4.0 | 1 | 4.97 |
| CHEMBL298398 | ANTHRAFLAVICACID | — | 1 | 4.94 |
| CHEMBL2180144 | — | — | 1 | 4.92 |
| CHEMBL29898 | QUINALIZARIN | — | 1 | 4.77 |
| CHEMBL179617 | — | — | 1 | 4.70 |
| CHEMBL486760 | XANTHENE | — | 1 | 4.61 |
| CHEMBL4740697 | — | — | 1 | 4.60 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 4.58 |
| CHEMBL5204890 | — | — | 1 | 4.55 |
| CHEMBL55761 | ANTHRARUFIN | — | 1 | 4.51 |
| CHEMBL2322655 | CINNABARINIC ACID | — | 1 | 4.34 |
| CHEMBL5173101 | — | — | 1 | 4.29 |
| CHEMBL5203113 | — | — | 1 | 4.07 |
| CHEMBL5172934 | — | — | 1 | 4.02 |
| CHEMBL55659 | ANTHRAQUINONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17594 | QUINIZARIN | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5201468 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL186784 | XANTHONE | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL86771 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5196838 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL124440 | ANTHRONE | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL89626 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL289277 | EMODIN | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL294264 | PURPURIN | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL53418 | DANTHRON | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL298398 | ANTHRAFLAVICACID | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL2180144 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL29898 | QUINALIZARIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL179617 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL486760 | XANTHENE | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4740697 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5204890 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL55761 | ANTHRARUFIN | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL2322655 | CINNABARINIC ACID | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL5173101 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5203113 | — | IC50 | = | 85600.0 | nM | 4.07 |
| CHEMBL5172934 | — | IC50 | = | 95100.0 | nM | 4.02 |
| CHEMBL55659 | ANTHRAQUINONE | IC50 | = | 122000.0 | nM | - |