Assay Detail
Binding
CHEMBL5144883
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Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence spectrophotometric assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.86 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201468 | — | — | 1 | 5.87 |
| CHEMBL89626 | — | — | 1 | 5.62 |
| CHEMBL289277 | EMODIN | — | 1 | 5.49 |
| CHEMBL179617 | — | — | 1 | 5.37 |
| CHEMBL298398 | ANTHRAFLAVICACID | — | 1 | 5.25 |
| CHEMBL486760 | XANTHENE | — | 1 | 5.13 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 4.66 |
| CHEMBL294264 | PURPURIN | — | 1 | 4.40 |
| CHEMBL53418 | DANTHRON | 4.0 | 1 | 4.23 |
| CHEMBL2322655 | CINNABARINIC ACID | — | 1 | 4.19 |
| CHEMBL2180144 | — | — | 1 | 4.04 |
| CHEMBL5204890 | — | — | 1 | 4.04 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | - |
| CHEMBL17594 | QUINIZARIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201468 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL89626 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL289277 | EMODIN | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL179617 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL298398 | ANTHRAFLAVICACID | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL486760 | XANTHENE | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL294264 | PURPURIN | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL53418 | DANTHRON | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL2322655 | CINNABARINIC ACID | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2180144 | — | IC50 | = | 91900.0 | nM | 4.04 |
| CHEMBL5204890 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 112000.0 | nM | - |
| CHEMBL17594 | QUINIZARIN | IC50 | = | 110000.0 | nM | - |