Assay Detail
Binding
CHEMBL5144932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK1 in human BT-474 cells assessed as reduction in AKT phosphorylation at T308 residue incubated for 2 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (CHEMBL4766) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and optimization of a novel series of selective PIP5K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206569 | — | — | 1 | 5.77 |
| CHEMBL5191668 | — | — | 1 | 5.72 |
| CHEMBL5171272 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206569 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5191668 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5171272 | — | IC50 | = | 4400.0 | nM | 5.36 |