Assay Detail
Binding
CHEMBL5145040
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Inhibition of Tag1-PD1/Tag2-PD2 interaction pre mixed with anti-Tagl-Eu 3 and anti-Tag2-XL665 incubated for 2 hrs bt HTRF assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCC4006 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.70 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089730 | — | — | 1 | 7.77 |
| CHEMBL5170724 | — | — | 1 | 7.21 |
| CHEMBL5207927 | — | — | 1 | 7.16 |
| CHEMBL5195987 | — | — | 1 | 7.13 |
| CHEMBL5207188 | — | — | 1 | 7.05 |
| CHEMBL5180749 | — | — | 1 | 7.01 |
| CHEMBL5198307 | — | — | 1 | 6.87 |
| CHEMBL5187889 | — | — | 1 | 6.74 |
| CHEMBL5205627 | — | — | 1 | 6.70 |
| CHEMBL5177863 | — | — | 1 | 6.65 |
| CHEMBL5180819 | — | — | 1 | 6.65 |
| CHEMBL5196223 | — | — | 1 | 6.60 |
| CHEMBL5176253 | — | — | 1 | 6.18 |
| CHEMBL5185361 | — | — | 1 | 5.46 |
| CHEMBL5188518 | — | — | 1 | 5.34 |
| CHEMBL5195360 | — | — | 1 | - |
| CHEMBL5188556 | — | — | 1 | - |
| CHEMBL5179775 | — | — | 1 | - |
| CHEMBL5190043 | — | — | 1 | - |
| CHEMBL5199460 | — | — | 1 | - |
| CHEMBL5180433 | — | — | 1 | - |
| CHEMBL5195782 | — | — | 1 | - |
| CHEMBL5206666 | — | — | 1 | - |
| CHEMBL5207297 | — | — | 1 | - |
| CHEMBL5182633 | — | — | 1 | - |
| CHEMBL5182749 | — | — | 1 | - |
| CHEMBL5193317 | — | — | 1 | - |
| CHEMBL5192053 | — | — | 1 | - |
| CHEMBL5194706 | — | — | 1 | - |
| CHEMBL5196535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089730 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5170724 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5207927 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5195987 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5207188 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5180749 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5198307 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5187889 | — | EC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5205627 | — | EC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5177863 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5180819 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5196223 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5176253 | — | EC50 | = | 667.0 | nM | 6.18 |
| CHEMBL5185361 | — | EC50 | = | 3436.0 | nM | 5.46 |
| CHEMBL5188518 | — | EC50 | = | 4516.0 | nM | 5.34 |
| CHEMBL5201836 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5196525 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5198821 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5182289 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5170375 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5169785 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5195121 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5186026 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5195360 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5188556 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5179775 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5190043 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5199460 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5180433 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5195782 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5206666 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5207297 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5182633 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5182749 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5193317 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5192053 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5194706 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5196535 | — | EC50 | > | 10000.0 | nM | - |