Assay Detail
Binding
CHEMBL5145227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex vivo agonist activity at GPR38 in rabbit duodenum muscle tissue assessed as intestinal contractile activity
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.15 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525634 | — | — | 1 | 9.64 |
| CHEMBL5196819 | — | — | 1 | 8.32 |
| CHEMBL5201797 | — | — | 1 | 8.14 |
| CHEMBL5197045 | — | — | 1 | 7.55 |
| CHEMBL489095 | CAMICINAL | 3.0 | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525634 | — | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL5196819 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5201797 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5197045 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL489095 | CAMICINAL | EC50 | = | 82.6 | nM | 7.08 |