Assay Detail
Binding
CHEMBL5145666
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Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.85 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171772 | — | — | 1 | 6.25 |
| CHEMBL5179459 | — | — | 1 | 6.05 |
| CHEMBL5175548 | — | — | 1 | 6.04 |
| CHEMBL5182602 | — | — | 1 | 6.02 |
| CHEMBL5170670 | — | — | 1 | 6.01 |
| CHEMBL5193214 | — | — | 1 | 5.67 |
| CHEMBL5199815 | — | — | 1 | 5.63 |
| CHEMBL5204764 | — | — | 1 | 5.61 |
| CHEMBL5170381 | — | — | 1 | 5.39 |
| CHEMBL5196322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171772 | — | Ki | = | 557.4 | nM | 6.25 |
| CHEMBL5179459 | — | Ki | = | 896.2 | nM | 6.05 |
| CHEMBL5175548 | — | Ki | = | 922.8 | nM | 6.04 |
| CHEMBL5182602 | — | Ki | = | 948.4 | nM | 6.02 |
| CHEMBL5170670 | — | Ki | = | 965.4 | nM | 6.01 |
| CHEMBL5193214 | — | Ki | = | 2119.3 | nM | 5.67 |
| CHEMBL5199815 | — | Ki | = | 2358.9 | nM | 5.63 |
| CHEMBL5204764 | — | Ki | = | 2463.8 | nM | 5.61 |
| CHEMBL5170381 | — | Ki | = | 4079.4 | nM | 5.39 |
| CHEMBL5196322 | — | Ki | > | 10000.0 | nM | - |