Assay Detail
Functional
CHEMBL5145687
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at GHS-R1a (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.64 | 9.11 |
| EC50 | 2 | 7.08 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319405 | — | — | 1 | 9.11 |
| CHEMBL3319223 | — | — | 1 | 8.17 |
| CHEMBL3798056 | — | — | 1 | 7.16 |
| CHEMBL506986 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319405 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL3319223 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3798056 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL506986 | — | EC50 | = | 100.0 | nM | 7.00 |