Assay Detail
Binding
CHEMBL5146126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli topoisomerase 4 assessed as reduction in decatenation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201228 | — | — | 1 | 8.00 |
| CHEMBL5198597 | — | — | 1 | 7.82 |
| CHEMBL5172158 | — | — | 1 | 7.77 |
| CHEMBL5182200 | — | — | 1 | 7.62 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 7.52 |
| CHEMBL3317856 | GEPOTIDACIN | 3.0 | 1 | 7.46 |
| CHEMBL5184104 | — | — | 1 | 7.00 |
| CHEMBL5195268 | — | — | 1 | 6.64 |
| CHEMBL5177076 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201228 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5198597 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5172158 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5182200 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3317856 | GEPOTIDACIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5184104 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5195268 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5177076 | — | IC50 | = | 4240.0 | nM | 5.37 |