Assay Detail
Toxicity
CHEMBL5146134
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Inhibition of human ERG by Ionworks electrophysiology assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.09 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205047 | — | — | 1 | 5.52 |
| CHEMBL5182200 | — | — | 1 | 5.40 |
| CHEMBL5201228 | — | — | 1 | 5.30 |
| CHEMBL5184352 | — | — | 1 | 5.30 |
| CHEMBL5194618 | — | — | 1 | 5.16 |
| CHEMBL5199405 | — | — | 1 | 5.16 |
| CHEMBL5172094 | — | — | 1 | 5.05 |
| CHEMBL5190832 | — | — | 1 | 5.00 |
| CHEMBL5195721 | — | — | 1 | 4.89 |
| CHEMBL5206169 | — | — | 1 | 4.70 |
| CHEMBL5184104 | — | — | 1 | 4.50 |
| CHEMBL5177076 | — | — | 1 | - |
| CHEMBL5198597 | — | — | 1 | - |
| CHEMBL5188163 | — | — | 1 | - |
| CHEMBL5170129 | — | — | 1 | - |
| CHEMBL5172158 | — | — | 1 | - |
| CHEMBL5195268 | — | — | 1 | - |
| CHEMBL5195428 | — | — | 1 | - |
| CHEMBL3317856 | GEPOTIDACIN | 3.0 | 1 | - |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205047 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5182200 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5201228 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5184352 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5194618 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5199405 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5172094 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5190832 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5195721 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5206169 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5184104 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5177076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5198597 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5188163 | — | IC50 | - | — | - | |
| CHEMBL5170129 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL5172158 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5195268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5195428 | — | IC50 | - | — | - | |
| CHEMBL3317856 | GEPOTIDACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL8 | CIPROFLOXACIN | IC50 | > | 100000.0 | nM | - |