Assay Detail
Binding
CHEMBL5146273
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Inhibition of CDK7 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.19 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3603847 | — | — | 1 | 8.49 |
| CHEMBL4434871 | — | — | 1 | 8.12 |
| CHEMBL4450322 | — | — | 1 | 8.01 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 7.21 |
| CHEMBL5202522 | — | — | 1 | 6.26 |
| CHEMBL4648857 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3603847 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4434871 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4450322 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5202522 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL4648857 | — | IC50 | = | 8500.0 | nM | 5.07 |