Assay Detail
Binding
CHEMBL5146285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human CDK2 expressed in baculovirus expression system using GST-RB fusion protein as substrate incubated for 45 mins in presence of [gamma-33P]ATP by liquid scintillation counter method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.23 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8817 | — | — | 1 | 6.77 |
| CHEMBL334881 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8817 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL334881 | — | IC50 | = | 2100.0 | nM | 5.68 |