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Assay Detail

CHEMBL5146827

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Functional
Antiviral activity against Human rhinovirus A71 infected in human H1-HeLa cells assessed as reduction in virus induced cytopathic effect incubated for 3 days by MTT assay
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus A71
Cell Type H1-HeLa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode.
Kumar Biswas B, Soo Shin J, Malpani YR, Hwang D, Jung E, Bong Han S, Vishakantegowda AG, Jung YS.
Bioorg Med Chem Lett (2022) 64 : 128673 -128673
PubMed 35292344 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.67 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29609 PLECONARIL 2.0 1 7.77
CHEMBL5173613 3 5.80
CHEMBL5169643 1 5.70
CHEMBL5204247 1 5.66
CHEMBL4059872 1 5.64
CHEMBL5187182 1 5.43
CHEMBL5196268 1 5.37
CHEMBL5204841 1 4.92
CHEMBL5172646 1 4.64
CHEMBL5190516 1 -
CHEMBL5180043 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29609 PLECONARIL EC50 = 17.0 nM 7.77
CHEMBL5173613 EC50 = 1600.0 nM 5.80
CHEMBL5173613 EC50 = 1700.0 nM 5.77
CHEMBL5173613 EC50 = 1900.0 nM 5.72
CHEMBL5169643 EC50 = 2000.0 nM 5.70
CHEMBL5204247 EC50 = 2200.0 nM 5.66
CHEMBL4059872 EC50 = 2300.0 nM 5.64
CHEMBL5187182 EC50 = 3700.0 nM 5.43
CHEMBL5196268 EC50 = 4300.0 nM 5.37
CHEMBL5204841 EC50 = 12100.0 nM 4.92
CHEMBL5172646 EC50 = 23000.0 nM 4.64
CHEMBL5190516 EC50 > 100000.0 nM -
CHEMBL5180043 EC50 > 100000.0 nM -