Assay Detail
Binding
CHEMBL5147057
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Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assay
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiosemicarbazone derivatives: Evaluation as cruzipain inhibitors and molecular modeling study of complexes with cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.00 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92099 | — | — | 2 | 7.70 |
| CHEMBL90512 | — | — | 2 | 7.30 |
| CHEMBL313679 | — | — | 2 | 7.00 |
| CHEMBL90866 | — | — | 2 | 6.66 |
| CHEMBL415311 | — | — | 2 | 6.34 |
| CHEMBL92579 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92099 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL92099 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL90512 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL90512 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL313679 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL313679 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL90866 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL90866 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL415311 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL415311 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL92579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL92579 | — | IC50 | > | 10000.0 | nM | - |