Assay Detail
Functional
CHEMBL5147196
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Anti-proliferative activity against human MDA-MB-231 assessed as cell growth inhibition measured after 48 hrs by Cell Titre Glo Luminescent Cell viability assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of small-molecule inhibitors of RUVBL1/2 ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.01 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203675 | — | — | 1 | 6.16 |
| CHEMBL5178717 | — | — | 1 | 5.05 |
| CHEMBL5203235 | — | — | 1 | 4.75 |
| CHEMBL5199847 | — | — | 1 | 4.66 |
| CHEMBL5193682 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203675 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5178717 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5203235 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5199847 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5193682 | — | IC50 | = | 37000.0 | nM | 4.43 |