Assay Detail
Toxicity
CHEMBL5147244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG channel expressed in HEK293 cells at -80 mV holding potential by automated patch clamp method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | — | 1 | 7.77 |
| CHEMBL5192409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5192409 | — | IC50 | > | 30000.0 | nM | - |