Assay Detail
Functional
CHEMBL5147326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-necroptic activity in human HT-29 cells assessed as inhibition of TSZ induced necroptosis measured after 16 to 24 hrs by celltiter-glo luminescent cell viability assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 6.14 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188220 | — | — | 1 | 8.60 |
| CHEMBL5209042 | — | — | 1 | 8.05 |
| CHEMBL5180233 | — | — | 1 | 8.05 |
| CHEMBL5177347 | — | — | 1 | 7.77 |
| CHEMBL5181292 | — | — | 1 | 7.44 |
| CHEMBL5183211 | — | — | 1 | 6.74 |
| CHEMBL5205368 | — | — | 1 | 6.68 |
| CHEMBL5185226 | — | — | 1 | 6.54 |
| CHEMBL5188420 | — | — | 1 | 6.44 |
| CHEMBL5190555 | — | — | 1 | 6.38 |
| CHEMBL5192442 | — | — | 1 | 6.29 |
| CHEMBL5209141 | — | — | 1 | 6.25 |
| CHEMBL5204963 | — | — | 1 | 6.09 |
| CHEMBL5206018 | — | — | 1 | 6.04 |
| CHEMBL5181537 | — | — | 1 | 6.00 |
| CHEMBL5187477 | — | — | 1 | 5.97 |
| CHEMBL5195401 | — | — | 1 | 5.91 |
| CHEMBL5193950 | — | — | 1 | 5.81 |
| CHEMBL5181126 | — | — | 1 | 5.80 |
| CHEMBL5193335 | — | — | 1 | 5.71 |
| CHEMBL5183398 | — | — | 1 | 5.65 |
| CHEMBL5195465 | — | — | 1 | 5.62 |
| CHEMBL5183031 | — | — | 1 | 5.62 |
| CHEMBL5184282 | — | — | 1 | 5.57 |
| CHEMBL5197698 | — | — | 1 | 5.55 |
| CHEMBL5209346 | — | — | 1 | 5.45 |
| CHEMBL5190483 | — | — | 1 | 5.44 |
| CHEMBL5183455 | — | — | 1 | 5.42 |
| CHEMBL5180814 | — | — | 1 | 5.40 |
| CHEMBL5190780 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188220 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5209042 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5180233 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5177347 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5181292 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5183211 | — | EC50 | = | 180.6 | nM | 6.74 |
| CHEMBL5205368 | — | EC50 | = | 208.5 | nM | 6.68 |
| CHEMBL5185226 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5188420 | — | EC50 | = | 359.6 | nM | 6.44 |
| CHEMBL5190555 | — | EC50 | = | 414.0 | nM | 6.38 |
| CHEMBL5192442 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5209141 | — | EC50 | = | 566.0 | nM | 6.25 |
| CHEMBL5204963 | — | EC50 | = | 805.0 | nM | 6.09 |
| CHEMBL5206018 | — | EC50 | = | 916.1 | nM | 6.04 |
| CHEMBL5181537 | — | EC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL5187477 | — | EC50 | = | 1066.0 | nM | 5.97 |
| CHEMBL5195401 | — | EC50 | = | 1231.0 | nM | 5.91 |
| CHEMBL5193950 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5181126 | — | EC50 | = | 1583.0 | nM | 5.80 |
| CHEMBL5193335 | — | EC50 | = | 1949.0 | nM | 5.71 |
| CHEMBL5183398 | — | EC50 | = | 2257.0 | nM | 5.65 |
| CHEMBL5195465 | — | EC50 | = | 2403.0 | nM | 5.62 |
| CHEMBL5183031 | — | EC50 | = | 2383.0 | nM | 5.62 |
| CHEMBL5184282 | — | EC50 | = | 2682.0 | nM | 5.57 |
| CHEMBL5197698 | — | EC50 | = | 2825.0 | nM | 5.55 |
| CHEMBL5209346 | — | EC50 | = | 3531.0 | nM | 5.45 |
| CHEMBL5190483 | — | EC50 | = | 3638.0 | nM | 5.44 |
| CHEMBL5183455 | — | EC50 | = | 3834.0 | nM | 5.42 |
| CHEMBL5180814 | — | EC50 | = | 3998.0 | nM | 5.40 |
| CHEMBL5190780 | — | EC50 | = | 3968.0 | nM | 5.40 |
| CHEMBL5204361 | — | EC50 | = | 4423.0 | nM | 5.35 |
| CHEMBL5189569 | — | EC50 | = | 4763.0 | nM | 5.32 |
| CHEMBL5197465 | — | EC50 | = | 5525.0 | nM | 5.26 |
| CHEMBL5186322 | — | EC50 | = | 6311.0 | nM | 5.20 |
| CHEMBL5187665 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5185311 | — | EC50 | > | 10000.0 | nM | - |