Assay Detail
Functional
CHEMBL5148126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human EC109 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ECa-109 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzobis(imidazole) derivatives as STAT3 signal inhibitors with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180786 | — | — | 1 | 5.44 |
| CHEMBL187460 | CRYPTOTANSHINONE | — | 1 | 5.30 |
| CHEMBL5175477 | — | — | 1 | 4.90 |
| CHEMBL5201305 | — | — | 1 | - |
| CHEMBL5188249 | — | — | 1 | - |
| CHEMBL5199746 | — | — | 1 | - |
| CHEMBL5199778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180786 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL187460 | CRYPTOTANSHINONE | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL5175477 | — | IC50 | = | 12580.0 | nM | 4.90 |
| CHEMBL5201305 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5188249 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5199746 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5199778 | — | IC50 | > | 20000.0 | nM | - |