Assay Detail
Functional
CHEMBL5148329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against NPM-ALK positive human KARPAS-299 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.71 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.70 |
| CHEMBL5179806 | — | — | 1 | 7.16 |
| CHEMBL5178030 | — | — | 1 | 7.10 |
| CHEMBL5194446 | — | — | 1 | 7.10 |
| CHEMBL5175979 | — | — | 1 | 7.05 |
| CHEMBL5185272 | — | — | 1 | 7.00 |
| CHEMBL5178177 | — | — | 1 | 7.00 |
| CHEMBL5183526 | — | — | 1 | 6.96 |
| CHEMBL5176307 | — | — | 1 | 6.96 |
| CHEMBL5184489 | — | — | 1 | 6.92 |
| CHEMBL5206284 | — | — | 1 | 6.89 |
| CHEMBL5178846 | — | — | 1 | 6.85 |
| CHEMBL5206622 | — | — | 1 | 6.85 |
| CHEMBL5195847 | — | — | 1 | 6.85 |
| CHEMBL5174878 | — | — | 1 | 6.82 |
| CHEMBL5170081 | — | — | 1 | 6.82 |
| CHEMBL5189267 | — | — | 1 | 6.77 |
| CHEMBL5182364 | — | — | 1 | 6.75 |
| CHEMBL5179387 | — | — | 1 | 6.68 |
| CHEMBL5169860 | — | — | 1 | 6.66 |
| CHEMBL5209011 | — | — | 1 | 6.64 |
| CHEMBL5189035 | — | — | 1 | 6.64 |
| CHEMBL5199005 | — | — | 1 | 6.60 |
| CHEMBL5203805 | — | — | 1 | 6.58 |
| CHEMBL5190549 | — | — | 1 | 6.57 |
| CHEMBL5203085 | — | — | 1 | 6.51 |
| CHEMBL5187826 | — | — | 1 | 6.50 |
| CHEMBL5206256 | — | — | 1 | 6.50 |
| CHEMBL5203218 | — | — | 1 | 6.47 |
| CHEMBL5178392 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5179806 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5178030 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5194446 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5175979 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5185272 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5178177 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5183526 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5176307 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5184489 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5206284 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5178846 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5206622 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5195847 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5170081 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5174878 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5189267 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5182364 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5179387 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5169860 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5209011 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5189035 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5199005 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5203805 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5190549 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5203085 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5187826 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5206256 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5203218 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5178392 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5209310 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5199475 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5187645 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5179262 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5174628 | — | IC50 | = | 1700.0 | nM | 5.77 |