Assay Detail
Binding
CHEMBL5148374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-vasopressin from human V1A receptor expressed in CHO cells membrane by microbeta scintillation counter analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzodiazepine Derivatives as Potent Vasopressin V<sub>2</sub> Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.68 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208751 | — | — | 1 | 6.83 |
| CHEMBL344159 | TOLVAPTAN | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208751 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL344159 | TOLVAPTAN | Ki | = | 296.0 | nM | 6.53 |