Assay Detail
Functional
CHEMBL5148375
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Antagonist activity at human V2 receptor expressed in CHO cells assessed as inhibition of vasopressin-induced cAMP accumulation incubated for 1 hr
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzodiazepine Derivatives as Potent Vasopressin V<sub>2</sub> Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.84 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208751 | — | — | 1 | 8.04 |
| CHEMBL5207885 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208751 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5207885 | — | IC50 | = | 23.0 | nM | 7.64 |