Assay Detail
Binding
CHEMBL5148669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length Mycobacterium tuberculosis protein kinase G using His-tagged GarA as substrate in presence of [gamma32P] ATP measured after 12 to 24 hrs by radiometric kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PknG (CHEMBL6070) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Cosolvent Sites-Based Discovery of <i>Mycobacterium Tuberculosis</i> Protein Kinase G Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.65 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379367 | — | — | 1 | 6.05 |
| CHEMBL5200480 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379367 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5200480 | — | IC50 | = | 5800.0 | nM | 5.24 |