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Assay Detail

CHEMBL5148672

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Functional
Antiproliferative activity against human A2780/CDDP cells assessed as cell growth inhibition measured after 48 hrs by MTS assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780/CDDP
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensitivity against MCF-7/ADR.
Yu Z, Li M, Wang K, Gu Y, Guo S, Wang W, Ma Y, Liu H, Chen Y.
J Med Chem (2022) 65 : 9328 -9349
PubMed 35737669 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 7.24 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5206322 1 8.10
CHEMBL5184181 1 7.93
CHEMBL5170844 1 7.92
CHEMBL5208832 1 7.84
CHEMBL5177197 1 7.60
CHEMBL4163642 1 7.58
CHEMBL5189359 1 7.50
CHEMBL5170139 1 7.47
CHEMBL5198848 1 7.42
CHEMBL5198369 1 7.39
CHEMBL5183745 1 7.33
CHEMBL5200387 1 7.19
CHEMBL5195004 1 7.17
CHEMBL5205132 1 7.14
CHEMBL3358557 1 7.13
CHEMBL5181909 1 7.13
CHEMBL5199563 1 7.09
CHEMBL5169594 1 7.02
CHEMBL5185480 1 7.01
CHEMBL5180904 1 6.94
CHEMBL5172687 1 6.88
CHEMBL5185070 1 6.84
CHEMBL5191677 1 6.72
CHEMBL5183639 1 6.63
CHEMBL5172373 1 6.12
CHEMBL74656 REL-CISAPRIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5206322 IC50 = 8.0 nM 8.10
CHEMBL5184181 IC50 = 11.7 nM 7.93
CHEMBL5170844 IC50 = 12.0 nM 7.92
CHEMBL5208832 IC50 = 14.4 nM 7.84
CHEMBL5177197 IC50 = 25.0 nM 7.60
CHEMBL4163642 IC50 = 26.3 nM 7.58
CHEMBL5189359 IC50 = 31.9 nM 7.50
CHEMBL5170139 IC50 = 33.7 nM 7.47
CHEMBL5198848 IC50 = 38.3 nM 7.42
CHEMBL5198369 IC50 = 40.6 nM 7.39
CHEMBL5183745 IC50 = 46.6 nM 7.33
CHEMBL5200387 IC50 = 64.6 nM 7.19
CHEMBL5195004 IC50 = 68.1 nM 7.17
CHEMBL5205132 IC50 = 72.6 nM 7.14
CHEMBL3358557 IC50 = 74.4 nM 7.13
CHEMBL5181909 IC50 = 73.2 nM 7.13
CHEMBL5199563 IC50 = 81.0 nM 7.09
CHEMBL5169594 IC50 = 96.2 nM 7.02
CHEMBL5185480 IC50 = 97.6 nM 7.01
CHEMBL5180904 IC50 = 114.3 nM 6.94
CHEMBL5172687 IC50 = 131.5 nM 6.88
CHEMBL5185070 IC50 = 143.8 nM 6.84
CHEMBL5191677 IC50 = 192.0 nM 6.72
CHEMBL5183639 IC50 = 233.0 nM 6.63
CHEMBL5172373 IC50 = 757.0 nM 6.12
CHEMBL74656 REL-CISAPRIDE IC50 > 200000.0 nM -