Assay Detail
Binding
CHEMBL5149150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TLR1/TLR2 in wild type C57BL/6J mouse macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 94 | 7.80 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205616 | — | — | 1 | 9.22 |
| CHEMBL5195088 | — | — | 1 | 9.17 |
| CHEMBL5191001 | — | — | 1 | 9.17 |
| CHEMBL5196750 | — | — | 1 | 9.15 |
| CHEMBL5179644 | — | — | 1 | 9.12 |
| CHEMBL5181631 | — | — | 1 | 9.12 |
| CHEMBL5183964 | — | — | 1 | 9.07 |
| CHEMBL5181859 | — | — | 1 | 9.00 |
| CHEMBL5192641 | — | — | 1 | 8.96 |
| CHEMBL5199615 | — | — | 1 | 8.92 |
| CHEMBL4472879 | — | — | 1 | 8.89 |
| CHEMBL5179849 | — | — | 1 | 8.89 |
| CHEMBL5190772 | — | — | 1 | 8.85 |
| CHEMBL5203424 | — | — | 1 | 8.82 |
| CHEMBL5169958 | — | — | 1 | 8.74 |
| CHEMBL5184916 | — | — | 1 | 8.70 |
| CHEMBL5169846 | — | — | 1 | 8.68 |
| CHEMBL5191273 | — | — | 1 | 8.68 |
| CHEMBL5206742 | — | — | 1 | 8.60 |
| CHEMBL5201759 | — | — | 1 | 8.59 |
| CHEMBL5170841 | — | — | 1 | 8.59 |
| CHEMBL5172228 | — | — | 1 | 8.55 |
| CHEMBL5198565 | — | — | 1 | 8.47 |
| CHEMBL5180856 | — | — | 1 | 8.47 |
| CHEMBL5203059 | — | — | 1 | 8.46 |
| CHEMBL5188254 | — | — | 1 | 8.43 |
| CHEMBL5169343 | — | — | 1 | 8.35 |
| CHEMBL5202312 | — | — | 1 | 8.33 |
| CHEMBL5208333 | — | — | 1 | 8.31 |
| CHEMBL5174119 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205616 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5195088 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL5191001 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL5196750 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5179644 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5181631 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5183964 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5181859 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5192641 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5199615 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4472879 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5179849 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5190772 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5203424 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5169958 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5184916 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5169846 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5191273 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5206742 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5201759 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5170841 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5172228 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5198565 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5180856 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5203059 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5188254 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5169343 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5202312 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5208333 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5174119 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5207112 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5186180 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5205724 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5187007 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5208283 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5205713 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5193298 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5205549 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5196411 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5191877 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5185241 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5193367 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5205005 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5197635 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5181846 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5188206 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5182713 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5176430 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5201813 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5190146 | — | EC50 | = | 19.0 | nM | 7.72 |